https://bugs.winehq.org/show_bug.cgi?id=34658
scix55@gmail.com changed:
What |Removed |Added ---------------------------------------------------------------------------- CC| |scix55@gmail.com
--- Comment #9 from scix55@gmail.com --- Force enabling the Large Address Aware flag may help with the issue: http://www.ntcore.com/4gb_patch.php
Steam might not like it so a crack could be needed. I haven't tested this workaround with Bioshock 2 but I have with the first game and it works there. It also works with Resident Evil : Remastered but a crack is required for that game.