http://bugs.winehq.org/show_bug.cgi?id=10773
--- Comment #5 from Stefan Dösinger stefandoesinger@gmx.at 2007-12-16 15:24:23 --- I tested that bug, and I could not reproduce it(nvidia card). I jumped a number of times(around 10, didn't count exactly), and I did not see any slowdown. There is no memory leak either. The memory usage goes up each jump in one direction, but that is normal as new parts of the universe are loaded. When jumping the same way back, the memory usage stays constant. Eventually eve will kick out old data from memory, then the memory usage goes down again.
Is it possible that you're running into some ATI driver bug? Current fglrx versions have an enourmous memory leak, at least on R500 cards. Running glxgears for 5 minutes leaks many hundret MBs of memory.