http://bugs.winehq.org/show_bug.cgi?id=15559
--- Comment #102 from Reece Dunn msclrhd@gmail.com 2009-02-28 06:11:04 --- I have been subscribed to the pulseaudio mailing list since I started investigating this issue in Wine. Of interest is https://tango.0pointer.de/pipermail/pulseaudio-discuss/2009-February/003150.....
Essentially, for the Linux distributions that do not have sound glitches (e.g. Fedora), they have very low scheduling latencies (around 5ms) whereas the ones that have glitches (e.g. Ubuntu) show a latency of around 210ms. It is this high latency that causes the ALSA audio buffer to run out before data is fetched again, and thus cause sound glitches.
This is no longer a Wine issue. It is an issue with pulseaudio and the Linux kernel configuration. If anybody is experiencing any further pulseaudio issues they should file a bug report with their distribution and point them to the link above.