http://bugs.winehq.org/show_bug.cgi?id=10026
--- Comment #2 from Lei Zhang thestig@google.com 2007-10-18 14:09:36 --- This may very well be a bug in the openchrome driver, which looks like it's still beta. Have you tried playing with the HWCursor or SWCursor options in your xorg.conf?
See the "my mouse cursor sometimes disappears" section on https://help.ubuntu.com/community/OpenChrome