https://bugs.winehq.org/show_bug.cgi?id=38043
--- Comment #3 from Ken Thomases ken@codeweavers.com --- For me, turning on Alternate Timing seems to get it to 60 FPS. That option is documented in the ReadMe.txt as:
Alternate Timing - Normally Regen uses sound card for timing but some sound cards have problems with this. This causes FPS being jumpy and video/sound being skippy. Enabling this will cause Regen to use other timers for timing to fix that problem. So if you are experiencing those problems try enabling this.
Does that work for you?