http://bugs.winehq.org/show_bug.cgi?id=24324
--- Comment #12 from A Wine user RandomAccountName@mail.com 2010-09-14 08:56:42 CDT --- (In reply to comment #11)
You are breaking it, the correct way to remove it is rm -rf .wine, not rm -rf .wine/*.
I can't do that when a file system is mounted at .wine:
rm -rf ~/.wine rm: cannot remove directory `/home/me/.wine': Device or resource busy
I'd have to umount tmpfs, remove the directory, recreate the directory, and remount tmpfs every time I want to make a fresh tmpfs-hosted prefix. That, or set WINEPREFIX to use a directory within my tmpfs file system instead of the root. I guess it isn't really a big deal, just less convenient that way.