[Bug 28035] Fallout 3 crashes when hitting play on launcher.

http://bugs.winehq.org/show_bug.cgi?id=28035

--- Comment #14 from Erich Hoover  2011-12-05 14:54:27 CST ---
(In reply to comment #13)
> Yup, tried that.
> Also force disabled all in-game overlay related settings in Steam too (btw, I
> don't think the original error posted by mister_a was using Steam -- so, I
> don't *think* this is a Steam overlay issue)

I bought the disk version and it still uses Steam.  Have you tried validating
your game files?