https://bugs.winehq.org/show_bug.cgi?id=42311
--- Comment #8 from Alexandre Julliard julliard@winehq.org --- (In reply to Jan Ziak (http://atom-symbol.net) from comment #5)
$ cd .wine $ rm -f *.reg
You should never do that. The registry won't be re-created to match the contents of the C drive, you'll just get a broken prefix. If you want a fresh prefix you have to remove the entire directory.