http://bugs.winehq.org/show_bug.cgi?id=26924
--- Comment #36 from Adam Martinson adam.r.martinson@gmail.com 2012-02-03 17:02:50 CST --- (In reply to comment #35)
-However- Thats from an already copied over install, downloading the League of Legends installer from the website (http://l3cdn.riotgames.com/Installer/NA_Installer/LeagueofLegends.exe) and trying to run that, it crashes. I'm not sure if that should be covered in this bug or not though..?
That sounds like bug 22152, it's a separate issue.