https://bugs.winehq.org/show_bug.cgi?id=54873
--- Comment #1 from Alexandre Julliard julliard@winehq.org --- Wow64 requires 64-bit components, which don't exist in a 32-bit prefix. Applications that don't support this won't be able to run (and presumably wouldn't run on recent Windows either).
If the issue is only the Windows version, then this could be faked, there's no reason we couldn't report an older version in Wow64. Other issues will need to be investigated on a per-app basis.