https://bugs.winehq.org/show_bug.cgi?id=56231
--- Comment #5 from Fabian Maurer dark.shadow4@web.de --- There isn't much to elaborate. It only updates its screen when on the first monitor, move it over to the second and it stops drawing its contents. Move it back and it continues drawing. Only seems to affect X11 and XWayland though.
Also keep in mind that the Myst thing is with using DosBox.