http://bugs.winehq.org/show_bug.cgi?id=16586
--- Comment #3 from Troy James Sobotka troy.sobotka@gmail.com 2008-12-21 18:30:42 --- I have attempted to launch it on both amd64 and i386 versions of Ubuntu.
Launching setup.exe from Nautilus (or the .msi installer for that matter), from the command line with full path to the DVD, etc., have all failed and result in the same error.