http://bugs.winehq.org/show_bug.cgi?id=13607
--- Comment #1 from Dmitry Timoshkov dmitry@codeweavers.com 2008-06-02 08:26:36 --- (In reply to comment #0)
Wine probably not handle properly some attributes of ZFS, so if your .wine/drive_c on ZFS volume, you will be unable to install most applications on it, the dialog box "Unsupported Cluster Size" pops up. Let me know, how we can further investigate that bug. Tested on 7.0-STABLE
That's not a Wine dialog. You need investigate where it comes from.