https://bugs.winehq.org/show_bug.cgi?id=46072
--- Comment #7 from Tom B tom@r.je --- Update: I modded the game to disable all NPC ship voices and engine noises, no stutter. As I suspected, it is completely audio related and I've even narrowed down the specific sounds that cause the problem. It's bizarre that other in-game sounds don't cause the same issue.
I also tried installing dsound via winetricks and setting it to native. The game definitely uses this dll but the native version made no difference.
Unfortunately I'm not sure what to try next.