https://bugs.winehq.org/show_bug.cgi?id=47115
--- Comment #2 from Tyler thezombiehunter@gmail.com --- No, it's not limited to the first explosion. For example, if you go into a military base and start blowing up gas tanks/etc it constantly stutters/freezes.
The freezing does affect car explosions as well, so if you're running from the military and a vehicle explodes behind you - it freezes.
It renders the game unplayable. The whole purpose of Just Cause 2 is to cause mayhem and destruction.
I don't know the internals of JC2. I do know that it updates statistics when an explosion happens, and it's possible it's updating to a save game on the cloud. If that's what's going on, then it's probably where the issue is.