https://bugs.winehq.org/show_bug.cgi?id=40032
--- Comment #4 from Matthew Krafczyk krafczyk.matthew@gmail.com --- Searching for the function 'SetProcessDpiAwareness', I localized the issue to be in the 'api-ms-win-Stub_DLLs' patchset.
Setting shcore to 'disabled' in winecfg allows StarCraft 2 to start normally.