https://bugs.winehq.org/show_bug.cgi?id=25912
--- Comment #71 from artik jeff.artik@gmail.com --- It seems latest Wine staging (4.12.1) fully or partially fix this bug, can we have more confirmations?
I tried Photoshop CC 2019, all works now (and with graphic acceleration!). The bug still occurs once when display/hide a layer, but all other functions are not delayed anymore.