https://bugs.winehq.org/show_bug.cgi?id=48207
--- Comment #4 from Ahmed Elsayed ahmed.com@protonmail.com --- Blacksad doesn't respond to keyboard, and controller input with WINE 4.21, but this issue doesn't exist with Proton 4.11-9, or WINE 4.19, because I played the game with that version before without any issues. Also, pressing alt + tab with Proton 4-11.9 doesn't freeze the game completely.
Devil May Cry 5 doesn't respond to keyboard, and controller input with WINE 4.21, but this issue doesn't exist with Proton 4.11-9. Also, pressing alt + tab with Proton 4-11.9 doesn't break keyboard, and controller input.
I will give these games a test with older versions of WINE to know when this regression exists.