http://bugs.winehq.org/show_bug.cgi?id=58482
--- Comment #8 from Karim A. karimri@protonmail.com --- The merge request does indeed fix the issue, It's just that the actual application itself has other problems that seem to be fixed by wine-staging. We're trying to at least get it fundamentally working again on mainline.
You can confirm what I've said above by compiling Wine with the patch from the merge request or just using the built artifacts on the GitLab's pipeline: https://gitlab.winehq.org/karim_adli/wine/-/jobs/173204
We also have reports from users using the Vinegar Flatpak (which has a custom staging version of Wine which had the MR applied to it) that Studio does work.
As sewn has mentioned, you could try using Vinegar from your distribution's repositories or by building it, as it automatically installs Studio and manages it.
Also VirtualProtectFromApp is likely used by both RobloxStudioBeta and RobloxCrashHandler, likely due to a library.