https://bugs.winehq.org/show_bug.cgi?id=43363
--- Comment #5 from Robert Walker bob.mt.wya@gmail.com --- Possibly a duplicate of: https://bugs.winehq.org/show_bug.cgi?id=6971 ??
Symptoms would be that the mouse cursor can leave the game window - when the game is run a Wine Virtual Desktop. Typically happens in a 2(+) monitor setup.