http://bugs.winehq.org/show_bug.cgi?id=12547
--- Comment #11 from Austin English austinenglish@gmail.com 2008-04-15 20:57:39 --- (In reply to comment #10)
(In reply to comment #9)
You said the game uses Safedisc, right?
Yes many people have mentioned this on different forums and even other bugs here on winehq.
Seems safedisc is your problem:
http://appdb.winehq.org/objectManager.php?sClass=version&iId=609