http://bugs.winehq.org/show_bug.cgi?id=27901
--- Comment #4 from Bryan Kadzban bz-wine@kdzbn.homelinux.net 2011-07-30 21:12:48 CDT --- OK, I've upgraded alsa-lib and alsa-utils to the current versions. (1.0.24.1 and 1.0.24.2, respectively.) No change.
I did manage to figure out why Unreal was crashing: the hardware acceleration setting was "full" by default. Given how many places explicitly said to set it to "emulation", I had assumed (yeah, I know) that "emulation" had become the default. (Also because many of those pages were pretty old.) It still pops relatively frequently in-game though.
And that setting has no effect on the test run, either.