http://bugs.winehq.org/show_bug.cgi?id=9455
--- Comment #28 from Aneesh quadomatic@gmail.com 2007-08-26 10:54:14 --- It's possible that the error you're getting when copying over the system32 folder, is not related to SafeDisc, but related to the bug with GameGuard:
http://bugs.winehq.org/show_bug.cgi?id=3952
That's already been confirmed as a bug...I'm not sure why it's labeled as an enhancement