https://bugs.winehq.org/show_bug.cgi?id=41305
--- Comment #8 from fjfrackiewicz@gmail.com --- (In reply to Josh from comment #7)
I didn't build it myself though. I'm simply using the binary releases grabbed via PlayOnLinux (which I only use for downloading Wine, I do everything else by hand). Don't they come with WoW64 support?
I'm quite surprised because I run a lot of old games in 64bit prefixes and have never encountered an issue that didn't occur in the 32bit counterpart. Also, note that I got it working with a 64bit prefix on Wine 1.6.2.
I wouldn't know how PlayOnLinux compiles their binaries, to be honest.
All I know is that in order to run a 32-bit application in a 64-bit prefix you must have WoW64 support (it's how Windows does this with 32-bit Windows applications). If your version of Wine 1.6.2 was built with WoW64 support and when you created a prefix with that version of Wine like so:
WINEPREFIX=$HOME/.wine winecfg wineboot
you basically created a 64-bit prefix that can run 32-bit applications because, again, it has WoW64 support. I have Wine 1.9.18 built with WoW64 support and I have tested this with running No Man's Sky, a purely 64-bit Windows application, and GOG Galaxy, an application that can only run in 32-bit mode as of right now, in the same prefix and at the same time.