http://bugs.winehq.org/show_bug.cgi?id=27779
--- Comment #74 from Alexey Loukianov mooroon2@mail.ru 2011-09-16 03:59:36 CDT --- (In reply to comment #73)
The bug also happens only when "Emulate a virtual desktop" is checked and checkbox "Automatically capture the mouse in full-screen windows". Unfortunately dual monitors users have to emulate the virtual desktop and then capture the mouse for being able to play.
I use nVIDIA TwinView dual monitor setup at home and have no problems playing games. The only trick I had to use is to setup separate metamodes for each resolution I want to be able to play fullscreen (i.e., while normally I've got both monitors active, one @1280x1024 and second @1680x1050 resulting in 2960x1050 metamode, I also set up two separate metamodes each having only one of the monitors active at it's native resolution). Emulating virtual desktop had been required only for a couple of games I had ever tested under Wine, one was Eve Online and I can't remember now which was the second one.
To the bottom line: I'm seeing this bug without emulated virtual desktop and without enabling automated capture of the mouse cursor for full-screen windows. The only trigger is (a) to have Steam running and (b) to have a full-screen game. Game hadn't be related to Steam, for ex. I've seen this bug in Starcraft II, Angry Birds and NFS4:HS having Steam running at background under the same wineserver.