http://bugs.winehq.org/show_bug.cgi?id=14538
--- Comment #4 from Tobias Jakobi liquid.acid@gmx.net 2008-07-17 15:45:11 --- "doesn't work" == "game does no receive any input of the mouse"
This applies to in-game scenes. The settings screen seems to receive events since I can assign MOUSE1 to the fire action.