http://bugs.winehq.org/show_bug.cgi?id=7229
--- Comment #18 from Nicholas Jones jones@twobit.net 2008-01-17 00:38:55 --- Dual core (X2) here.
Setting the affinity seems to have masked the problem for me. I have not experienced the timeouts today. Good idea and temporary fix, by the way. :)
Bleeter, do you have anything running with a high priority that could be preempting the wine process(es)? You might try killing extraneous processes and adjust priorities if there is anything running with a higher-than-zero niceness.
Any suggestions on diagnosing this further?