http://bugs.winehq.org/show_bug.cgi?id=20469
--- Comment #10 from knan-wine@anduin.net 2009-11-11 15:09:35 --- Yes. Well, in addition, turn off frame buffer effects in the game settings, turn on multisampling in the wine registry, turn on antialiasing in the game settings. That seems to be enough to fix the flickering here.
Then add the patch from bug 9717 to fix cosmetic bugs appearing once you've got rid of the flicker.