http://bugs.winehq.org/show_bug.cgi?id=10040
--- Comment #2 from Vitaliy Margolen vitaliy@kievinfo.com 2007-11-07 14:57:41 --- That key is random and assigned during the install of the OS. msdn has few notes about when this can change as well.
In either case, this can't be something hard-coded in wine.inf for example. This _have to be_ randomly generated during the creation of the WINEPREFIX. The simplest solution would be use of "uuidgen" program (see Steam's HOWTO on appDB).