http://bugs.winehq.org/show_bug.cgi?id=31563
--- Comment #3 from Bruno Jesus 00cpxxx@gmail.com 2012-09-01 07:55:55 CDT --- Is it really supposed to work in 9600? The following line looks suspicious: warn:comm:get_hand_flow ioctl error 'Argument invalide'
You have to select the serial port in the application? Since it's a usb-serial device the port name is something like /dev/ttyUSB0 ? Are you in the dialout group?
You could try reading http://www.winehq.org/docs/wineusr-guide/misc-things-to-configure