http://bugs.winehq.org/show_bug.cgi?id=31839
--- Comment #5 from Erich Hoover ehoover@mines.edu 2012-10-01 15:50:47 CDT --- (In reply to comment #4)
I have removed LXDE with Openbox, installed Unity with Compiz and rebooted my system but the problem still exists without any difference.
That's very odd, I launched D3 exactly how you specified and my mouse is still exactly where it was when I started the application. Do you have the games set to use a different resolution from your normal desktop?