[Bug 49208] New: Wine cannot boot on a clean environment: failed to boot L"C:\\windows\\system32\\explorer.exe"

[WineHQ Bugzilla]

https://bugs.winehq.org/show_bug.cgi?id=49208

Bug ID: 49208
           Summary: Wine cannot boot on a clean environment: failed to
                    boot L"C:\windows\system32\explorer.exe"
           Product: Wine-staging
           Version: 5.8
          Hardware: x86-64
                OS: Linux
            Status: UNCONFIRMED
          Severity: blocker
          Priority: P4
         Component: -unknown
          Assignee: [e-mail]
          Reporter: [e-mail]
                CC: [e-mail], [e-mail]
      Distribution: Fedora

Created attachment 67216
  --> https://bugs.winehq.org/attachment.cgi?id=67216
Output of `wineboot` on a clean environment, Fedora 32, wine-staging 5.8.

Hi.

On a clean environment, Wine cannot boot due to errors. No program is trying to
be run, only running `wineboot` command. The log is attached.

Main errors IMHO:

0028:002c:err:module:__wine_process_init failed to load
L"C:\windows\system32\wineboot.exe", error c0000018
0020:0024:err:environ:run_wineboot failed to start wineboot c0000018
...
0030:0034:err:module:__wine_process_init failed to load
L"C:\windows\system32\wineboot.exe", error c0000018
0020:0024:err:wineboot:main failed to restart 64-bit
L"C:\windows\system32\wineboot.exe", err 487
...
0038:003c:err:module:__wine_process_init failed to load
L"C:\windows\system32\explorer.exe", error c0000018
...
wineserver: could not save registry branch to system.reg : No such file or
directory
wineserver: could not save registry branch to user.reg : No such file or
directory

Environment:
Wine-staging 5.8
OS: Fedora 32
Linux kernel: 5.6.12-300
WINEDEBUG=+process,+pid,+wineboot