https://bugs.winehq.org/show_bug.cgi?id=46039
--- Comment #12 from C. Leu kle@bluewin.ch --- A new addition.
The original mentioned installer crash because of a ".NET 4.5 limitation" in Mono seems no longer present. However, the installer still crashes almost instantly because of an "unimplemented Direct2D" feature.
For more details see the added log file of Paint.NET 4.0.8.
Probably I will open a new bug report targeting that specific Direct2D bug in Paint.NET 4.x based releases.