https://bugs.winehq.org/show_bug.cgi?id=42768
--- Comment #3 from Aexander kq3thih@mailnesia.com --- (In reply to Jactry Zeng from comment #1)
Which version of Ys VI did you test with? I tested it with one from Steam and it worked for me. How about using builtin amstream and quartz?
GOG version, standalone installer. Also, I was using the ys6_win_dx9.exe, but checking the DX10? EXE, ys6_win.exe, crashes the same way for me.
Using builtin amstream and quartz the videos are silently skipped, but the game proceeds fine otherwise.