https://bugs.winehq.org/show_bug.cgi?id=49752
--- Comment #15 from amad4wine2020@gmail.com --- (In reply to Roman Pišl from comment #14)
Emulating some Windows serial line modes is tricky and this is the case. What kind of device do you have connected? Is it RS232 or RS485? What type of serial line chip do you have on your computer? Or is it USB converter?
The connected device is: MCU-01 USB/RS485 OPTO-ISOLATED CONVERTER (https://mikster.eu/en/produkty/mcu-01-usbrs485-opto-isolated-converter/)