https://bugs.winehq.org/show_bug.cgi?id=49315
--- Comment #13 from Jason Bagavatsingham jason.bagavatsingham@gmail.com --- (In reply to Sergey Alirzaev from comment #12)
(In reply to Jason Bagavatsingham from comment #10)
I've also confirmed that on Proton 6.3-5-RC, you can proceed into game and play.
Do i get it right that the gameplay works for you, i.e. you can control civ6 with your mouse?
I don't know about upstream Wine, but yes, mouse input is functional on Proton for me.