https://bugs.winehq.org/show_bug.cgi?id=39859
--- Comment #3 from Vincent Povirk madewokherd@gmail.com --- Even if you understand the dialogs and always go through with them, the download process halts prefix creation indefinitely, and if you're not paying attention Wine can time out and start the program before the prefix has been fully created.
That's an issue that may be worth addressing separately, but installing packages for gecko and mono would prevent that situation.