https://bugs.winehq.org/show_bug.cgi?id=43083
winetest@luukku.com changed:
What |Removed |Added ---------------------------------------------------------------------------- CC| |winetest@luukku.com
--- Comment #1 from winetest@luukku.com --- You really shouldnt have opened this bug report. There are other bugs open about Fallout 4 not working. It doesn't help a bit to open new ones before they are fixed. You are just making this report dupe of the existing ones.
Start a new shell, ctrl+alt+f1 or soem other f-key. login, type wineserver -k or type alt+f2 and type wineserver -k.
That should prevent the need of reboot.
See bug 39586 bug 40046 comment 9 bug 41890 bug 41271
Basically there are 2 bugs now that are dupes and don't bring anything to the table.