http://bugs.winehq.org/show_bug.cgi?id=17267
--- Comment #3 from Philipp N. betadog@gmx.net 2009-02-05 12:14:51 --- (In reply to comment #1)
I'm not sure what you mean by this. Out of curiousity: do you run a second monitor? If so, do you run Xinerama or Dual View?
Xinerama is known to "detach" mouse input once in a while, freaky bug -- but nothing to do with keyboard input.
180.22 driver with clean wine-1.1.14 wineprefix should work just fine. Install it from the official nvidia website if anything.
Same problem with nvidia driver 180.22 and clean prefix.