https://bugs.winehq.org/show_bug.cgi?id=48647
--- Comment #15 from bugzilla@ekriirke.net --- My WINE also stopped working very recently. Not even winecfg would work. However if I made a new prefix it would. My original would start and stall like so: $ winecfg 000f:err:service:process_send_command receiving command result timed out 000f:fixme:service:scmdatabase_autostart_services Auto-start service L"WineBus" failed to start: 1053 0027:err:winediag:nodrv_CreateWindow Application tried to create a window, but no driver could be loaded. 0027:err:winediag:nodrv_CreateWindow The explorer process failed to start. 0027:err:ole:apartment_createwindowifneeded CreateWindow failed with error 3 0027:err:ole:apartment_createwindowifneeded CreateWindow failed with error 0 0027:err:ole:apartment_createwindowifneeded CreateWindow failed with error 0 0009:err:winediag:nodrv_CreateWindow Application tried to create a window, but no driver could be loaded. 0009:err:winediag:nodrv_CreateWindow The explorer process failed to start.
So I found the WineBus entry in system.reg [System\CurrentControlSet\Enum\ROOT\WINE\WINEBUS] 1582966719 #time=1d5eede6f8dea64 "Class"="System" "ClassGUID"="{4D36E97D-E325-11CE-BFC1-08002BE10318}" "DeviceDesc"="Wine HID bus driver" "Driver"="{4D36E97D-E325-11CE-BFC1-08002BE10318}\0000" "HardwareId"=hex(7):72,00,6f,00,6f,00,74,00,5c,00,77,00,69,00,6e,00,65,00,62,\ 00,75,00,73,00,00,00,00,00,00,00,00,00,46,00,61,00,69,00,6c,00,65,00,64,00,\ 20,00,74,00,6f,00,20,00,73,00,65,00 "Service"="winebus"
Deleted it, and now WINE works great.