https://bugs.winehq.org/show_bug.cgi?id=48225
--- Comment #2 from Matthew Reed wine@zootal.com --- The default for the version of Slackware I use is 1024. I've been using linux for 15 years or so, and I've never need to change this. Everything I do, including running a 7D2D server, four half-life servers, and four minecraft servers on my game server box, works just fine with this limit.
For the purposes of testing this game, I have increased it all the way up to 65535, and the only difference it makes is that it runs a bit longer before it crashes. Something (the game, a wine lib?) continuously opens files and does not release the handle, and eventually the max is reached, and it crashes.