http://bugs.winehq.org/show_bug.cgi?id=32261
Austin English austinenglish@gmail.com changed:
What |Removed |Added ---------------------------------------------------------------------------- Status|UNCONFIRMED |RESOLVED Resolution| |INVALID
--- Comment #6 from Austin English austinenglish@gmail.com 2012-11-21 13:59:41 CST ---
fixme:gameux:GameExplorerImpl_VerifyAccess (0x12e858, L"Z:\media\Storage\ME3\Mass Effect 3\Binaries\Win32\MassEffect3.exe", 0x1fee394)
As joaopa said, install the game under wine, without running it from a windows partition.