http://bugs.winehq.org/show_bug.cgi?id=9453
--- Comment #2 from Dan Kegel dank@kegel.com 2007-08-25 19:48:50 --- Note that winebrowser/main.c handles this option, too. But that doesn't help apps that invoke iexplore directly.
wine.inf itself specifies -nohome in a few places, too, as of this commit: http://source.winehq.org/git/wine.git/?a=commitdiff;h=fe07efb3dc37463c4288f7... though that's sent to winebrowser, not iexplore.