http://bugs.winehq.org/show_bug.cgi?id=15524
--- Comment #2 from Vitaliy Margolen vitaliy@kievinfo.com 2008-10-05 12:30:34 --- They actually might. As example S.T.A.L.K.E.R. - Shadow of Chernobyl US version has no copy protection and runs as-is. Russian and I think world versions have copy protection and don't work on Wine as-is.
However this does not warrant separate versions in AppDB. It will be too confusing and will bloat already huge list of applications.