http://bugs.winehq.org/show_bug.cgi?id=22724
--- Comment #6 from Dmitry Timoshkov dmitry@codeweavers.com 2010-05-17 04:52:23 --- Something is wrong with your configuration, winecfg in gnome works just fine here and for many other users.
Do you have 3d desktop effects enabled, or anything else not standard?