http://bugs.winehq.org/show_bug.cgi?id=30849
--- Comment #43 from Paul brenix@gmail.com 2012-06-07 01:18:56 CDT --- Try running the following to launch the game (assuming your in the Diablo 3 directory).. It works for getting past Retrieving hero list for me when launching it normally doesnt..This was taken from another user on the blizzard forums..
setarch i386 -3 -L -B -R wine Diablo\ III.exe -launch -locale enUS