http://bugs.winehq.org/show_bug.cgi?id=23135
--- Comment #34 from Daniel Harvison sirbubbles01@yahoo.com.au 2011-01-02 05:37:14 CST --- I've done some playing around with wine versions and mass effect 2 lately, and I can definitively say that Mass Effect 2 doesn't have this problem with wine 1.2-rc1, and the game seems to behave itself with this version of wine. If you try it with rc3 and any other more recent version of wine though, it causes problems as described in this bug, and when loading save games and loading levels.
I'd like to do some more involved bug testing, but don't think I have the skills. Can anyone help me?