https://bugs.winehq.org/show_bug.cgi?id=46870
--- Comment #30 from imbert.jacquesolivier@gmail.com --- And remember, from Riot :
https://boards.na.leagueoflegends.com/en/c/bug-report/sB4ucqXc-game-client-a...
""" We've not specifically tested for compatibility with Wine or other Windows emulation or virtualization software. Because of the complex nature of our protection and the many variations of software out there, we can't change our solution to be compatible with all of them. However, we are open to working with any software vendor that wants to make their software compatible. """
If the solution of Wine is "Use an program to modify official files of LOL", you can skip that definitively : this will ban players.
And I think it will be no difficult to talk with Riot to find solutions.