http://bugs.winehq.org/show_bug.cgi?id=14394
--- Comment #16 from Patrick McFarland diablod3@gmail.com 2010-04-24 04:51:20 --- It may actually effect HL2 as well, but I'm not entirely sure. Playing HL2 requires about two hours for it to lock up, and it may not be the same issue at all.
If it is the same bug, then TF2 is triggering it in ten minutes where HL2 takes over two hours. Portal seems to take more than that.