https://bugs.winehq.org/show_bug.cgi?id=49160
--- Comment #5 from Hans Leidekker hans@meelstraat.net --- With commit f516a23041b3871625764611321250f977fe750a we retrieve the OS serial number from the registry. It's the ProductId value under HKLM\Software\Microsoft\Windows NT\CurrentVersion.
With commit 84857d27067afaa1ae5774afe27086332263bfb5 we get the disk drive serial number from dbus. Note that this currently only works for drive c: in the default configuration.
Can you retest?